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Ming W Chou Selected Research

DNA Adducts

3/2010High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo.
5/2008Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
1/2006Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.
11/2004Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats.
5/2004Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook.
4/2004Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice [Cancer Lett. 193 (2003) 119-125.
12/2003Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine.
4/2003Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice.
1/2003Human liver microsomal metabolism and DNA adduct formation of the tumorigenic pyrrolizidine alkaloid, riddelliine.

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Ming W Chou Research Topics

Disease

13Neoplasms (Cancer)
04/2011 - 07/2002
3Hemangiosarcoma (Angiosarcoma)
11/2004 - 04/2003
2Body Weight (Weight, Body)
11/2004 - 06/2004
2Carcinogenesis
04/2004 - 04/2003
1Diabetes Mellitus
04/2011
1Infertility (Sterility)
04/2011
1Obesity
04/2011
1Neurodegenerative Diseases (Neurodegenerative Disease)
04/2011
1Dehydration (Water Stress)
05/2004

Drug/Important Bio-Agent (IBA)

11riddelliineIBA
05/2008 - 07/2002
9DNA AdductsIBA
03/2010 - 01/2003
8Pyrrolizidine AlkaloidsIBA
03/2010 - 01/2003
3dehydroretronecineIBA
05/2008 - 05/2004
3retronecineIBA
05/2008 - 05/2004
2clivorineIBA
05/2008 - 05/2004
2DNA (Deoxyribonucleic Acid)IBA
05/2004 - 01/2003
1Mitochondrial DNA (mtDNA)IBA
04/2011
1Fatty Acids (Saturated Fatty Acids)IBA
04/2011
1otonecineIBA
05/2008
1retrorsine (usaramine)IBA
05/2008
1MonocrotalineIBA
05/2008
1lasiocarpineIBA
05/2008
1SolventsIBA
11/2002
1Benzo(a)pyreneIBA
11/2002
14-biphenylamineIBA
11/2002